I can share my experiences with this.
I have tried both duromine and reductil, both with success, the most being with duromine. In saying that I also had the most side affects with duromine. Initially dry mouth, energy levels high and headache, sleeplessness ,MOODY, and a complete disinterest in food.
I lost about 20 kg on this. After 6 months on the same dose my body became used to it. My weight plateued and the last 5 kg not budging.
Reductil on the other i had no side affects, defnitley supressed my appetite without feeling like i was on speed.(but not as quick)
I think it all depends how sensitive each individual is to medication. I kept the weight off after i ceased taking duromine. I stayed the same weight for 3 years without it. Over the last year have had a baby and am still 8 kg overweight. This is not enough for a doc to prescribe me any form of weightloss medication.
Overall duromine was extreme but did do the job. I can not stress enough though how crap it was to be physically exhausted but my head still going, and not switching off. This was only for the first 3 weeks. For others it may have different, (worse possibly) side affects. But yes it worked.