- Home
- Supplements
- Apple Cider Vinegar
Apple Cider Vinegar for Weight Loss
Evidence Rating
Evidence Rating
Weak
Minimal evidence, failed trials, or very small effects
The most prominent weight loss study was retracted by BMJ in September 2025 due to improbable data. Remaining evidence is from small, poor-quality trials. Any weight loss effect is likely very small and unreliable.
Apple Cider Vinegar Key Facts
Probably not meaningfully
The most famous ACV weight loss study (Khandouzi 2024) was retracted by BMJ in September 2025 due to improbable data. Remaining evidence is weak, short-term, and from small studies.
Acetic acid may reduce appetite
Proposed mechanisms include slowed gastric emptying, increased satiety hormones (GLP-1, PYY), and AMPK activation. Mostly demonstrated in animal studies, not reliably in humans.
Can damage tooth enamel
Liquid ACV (pH 2.5-3.0) erodes tooth enamel. Can irritate the throat and oesophagus undiluted. Gummies are safer but contain far less active ingredient. Long-term high-dose use risks hypokalaemia.
Yes, everywhere
Liquid ACV in any supermarket. Supplement gummies and capsules at pharmacies and health stores. No prescription required.
$3-25 per month
Liquid ACV: $3-8 per bottle (750 mL-1 L), lasting 1-2 months. Swisse ACV gummies: ~$25/month at Chemist Warehouse.
No
Available as a food product (liquid) or over-the-counter supplement (gummies/capsules). No prescription required.
How Apple Cider Vinegar Claims to Work
Acetic acid may slow gastric emptying (increasing fullness) and activate AMPK in the liver to promote fat oxidation. However, much of this evidence comes from animal studies, and the extent to which these mechanisms operate meaningfully in humans at dietary doses is unclear.
What the Research Shows
Castagna et al. - Meta-analysis of 10 RCTs
Body weight SMD: -0.39; BMI SMD: -0.65; waist circumference SMD: -0.34 (all statistically significant but small effect sizes from mostly low-quality studies)
Nutrients
789 participants across 10 RCTs
Khandouzi et al. - RCT (RETRACTED)
RETRACTEDRETRACTED September 2025. Originally claimed ~9% body mass loss over 12 weeks. BMJ retracted due to improbable data distributions, unreplicable analyses, and no prospective trial registration.
BMJ Nutrition, Prevention & Health
120 participants
Malbouby, Trexler & Heathers - Statistical analysis
Used SPRITE analysis to demonstrate that the data distributions in the Khandouzi study were statistically improbable, with nearly identical age/BMI distributions across randomised groups.
BMJ Nutrition, Prevention & Health
Source data from published peer-reviewed studies. Links open in a new tab to external medical databases.
Side Effects & Risks
Common
- Tooth enamel erosion (pH 2.5-3.0; enamel weakens at pH 5.5)
- Nausea, especially on an empty stomach
- Throat and oesophageal irritation
Serious / Contraindications
- Oesophageal ulceration from undiluted use
- Gastroparesis risk (dangerous for Type 1 diabetes)
- Hypokalaemia (low potassium) with chronic high-dose use
- Interaction with diuretics and insulin (additive hypokalaemia/hypoglycaemia)
Australian Regulatory Status
Frequently Asked Questions
Other Supplements Reviewed
Berberine for weight loss
Evidence: Moderate | $35-75/mo
Protein Powder for weight loss
Evidence: Strong | $30-90/mo
Weight Loss Patches for weight loss
Evidence: None | $10-50/mo
Natural Appetite Suppressants for weight loss
Evidence: Moderate | $10-40/mo
Peptides for Weight Loss for weight loss
Evidence: Weak | $150-450/mo
Lemon Balm for weight loss
Evidence: None | $15-40/mo
Pink Salt (Himalayan Salt) for weight loss
Evidence: None | $1-5/mo
Medical disclaimer: This website is for informational purposes only. We are not medical professionals and nothing on this page constitutes medical advice, diagnosis, or treatment. Supplements are not a substitute for evidence-based medical treatment. Always consult a qualified doctor, pharmacist, or accredited practising dietitian before starting any supplement.
Supplements listed as AUST L on the Australian Register of Therapeutic Goods have been assessed by the TGA for safety and quality only, not for efficacy. An AUST L listing does not mean the TGA has verified that a supplement works for weight loss.
Data sourced from PubMed, Cochrane, TGA ARTG, FSANZ, and published clinical trial data. Last reviewed April 2026.